Mossel Bay is situated along the [wiki=f8dca86e19d3e834a0a6b4e27db712c6]Garden Route[/wiki], connected with the N2 and therefore easily reached from [wiki=5a6e47df50f895eec53a4dd2fe2393de]Cape Town[/wiki] in the West and [wiki=578ad8e10dc4edb52ff2bd4ec9bc93a3]George[/wiki] in the East, as well as [wiki=beaf9b680daa1d2c2fc5e636049d1ff9]Oudtshoorn[/wiki] in the North.
There is a daily train to [wiki=578ad8e10dc4edb52ff2bd4ec9bc93a3]George[/wiki] via Hartenbos, Great Brak River and Little Brak River.
This service will only operate as long as the regular Outeniqua Choo Tjoe[url=http://www.onlinesources.co.za/chootjoe]]train between [[George[/url]] and [wiki=2f625bfc391c37f1f239521bf54d2a40]Knysna[/wiki] is suspended (due to severe flooding and landslides in 2006).