Sano station is centrally located and can be reached by both JR Ryōmō Line (両毛線) and the Tōbu Sano Line (東武佐野線).
The bus terminal in Sano is located near the Sano Premium Outlets.
By taking JR Highway Bus "Marronier Shinjuku" or "Marronier Tokyo", you can get to Shinjuku, Ueno, and Tokyo JR Stations within 90 minutes. Tickets cost around ¥1,440 one way and can be purchased at the bus terminals in each JR station, the Sano Bus Terminal, online, and through some convenience store ticket terminals.
Direct access to and from Narita Airport is available through Highway Bus "Salvia" or Chiba Kotsu Bus. It takes about 130 minutes. This can be purchased at Narita Airport transportation counter (ask for Sano, Tochigi prefecture) or at the Sano Bus Terminal. Cost is about ¥4,400.
Take the Sano-Fujioka exit from the Tōhoku Expressway and follow National Route 50 west toward Sano,Ashikaga.