From Hefei, the province's capital city, there is a frequent train connection to Wuhu which takes approximately 2 hours. Wuhu is the second stop from Hefei.
From Nanjing there is also a frequent train to Wuhu which takes approximately 2 hours. Wuhu is the second stop (first stop: Ma'anschan).
From Shanghai, first take a train to Nanjing (High-speed train takes 2 hours for under ¥100). Then proceed from Nanjing.
Direct bus service to Wuhu is available at least once a day from Nanjing and Shanghai. From Nanjing, the ride takes 3 hours, from Shanghai 6 hours.