Pullman and Chevallier run buses from the Retiro Bus Terminal in Buenos Aires between 6.05am and 12.45am, with approximately 18 daily departures. The journey costs between Ar$29 and Ar$37 and takes about two hours. There are also several daily departures from Rosario, costing Ar$60 and taking about four hours.
San Antonio de Areco is accessible by car from Buenos Aires along National Route 8.